Optimizing the Benefits of BCMA-Targeted CAR T-Cell Therapy in Multiple Myeloma

摘要

SL BCMA is an important target because it is highly and almost ubiquitously expressed on plasma cells. The ligands for BCMA are often found in the plasma. Binding between BCMA and its ligands results in activation and proliferation of plasma cells, which can be linked to drug resistance. BCMA is therefore a good target from the perspectives of availability and access. BCMA is also responsible for many of the harmful effects of malignant plasma cells, which can complicate sensitization to existing therapies. Interrupting BCMA signaling and using BCMA as a therapeutic target can help kill plasma cells in more than one way.