Identification of peptides as a molecular glue for polytetrafluoroethylene

摘要

Polytetrafluoroethylene (PTFE) has widely been used in essential daily items and biomedical materials. The application range of PTFE should be greatly expanded if it can be flexibly functionalized. However, the functionalization method is still limited. In this study, peptides with affinity to PTFE were identified through affinity-based selection from a phage-displayed peptide library. The peptides had potential as a molecular glue to immobilize functional proteins and biomolecular assemblies, i.e., phages, onto PTFE films.