Guillain-Barre syndrome associated with rapid immune reconstitution following allogeneic hematopoietic stem cell transplantation.

摘要

Guillain-Barre syndrome (GBS) is a rare complication following hematopoietic stem cell transplantation (HSCT), and its pathogenesis remains unclear. GBS in the early post transplant period has been attributed to the conditioning regimen, particularly cytosine arabinoside.1 In contrast, the etiology of GBS in the late post transplant period remains unknown.2 Some reports suggest an association with antecedent infections such as cytomegalovirus (CMV) and Campylobacter pylori. As few cases of GBS during acute graft-versus-host disease (acute GVHD) have been reported, acute GVHD is unlikely to be the cause of GBS.2 We report a patient who developed GBS during rapid immune reconstitution following allogeneic HSCT.