Kikuchi-Fujimoto disease after allogeneic hematopoietic SCT mimicking post transplant lymphoproliferative disorder.

摘要

Post transplant lymphoproliferative disorders (PTLDs) comprise a heterogenous group of diseases featuring lymphoid proliferations, which have been a well-recognized complication of solid organ and hematopoietic SCT (HSCT) and should be one of the distinguishing characteristics for the differential diagnoses of 'lymph node enlargement' after transplantation. The worst form of PTLD is the monoclonal proliferation of B cells with the pathological features of diffuse large B-cell lymphoma. Kikuchi-Fujimoto disease (KFD), or necrotizing histiocytic lymphadenitis, is generally considered as a benign and self-limited disease due to viral infection. Although KFD is rarely seen in transplant recipients, it can be frequently misdiagnosed as malignant lymphoma. Here, we present a patient with documented KFD that developed early after allogeneic HSCT with clinical presentation being undiffer-entiable to PTLD.