Diagnosis and management of postural orthostatic tachycardia syndrome

摘要

The main characteristic of postural orthostatic tachycardia syndrome (POTS) is tachycardia when standing, without a drop in blood pressure. Patients describe lightheadedness and palpitations when upright, particularly when standing, which sometimes leads to syncope. Patients may experience impaired quality of life and functional disability, which can be economically devastating. The syndrome is more common in girls and young women and has been associated with other disorders, like migraine and Ehlers-Danlos syndrome. We discuss the diagnosis of POTS, conditions to consider in the differential diagnosis, associated disorders and the pharmacologic and nonphar-macologic management of patients with POTS, based on original research, narrative reviews and consensus statements (Box 1).