EBV-associated post transplant lymphoproliferative disorder of the 'loser' graft cell origin following double unrelated umbilical cord blood transplantation.

摘要

Post transplant lymphoproliferative disorders (PTLD) are life-threatening complications of hematopoietic SCT as well as organ transplantation, caused by EBV-driven B-cell growth combined with defective T-cell immunity. PTLD mostly occurs during the first 6 months after hematopoietic SCT and originates from the donor cell compartment; however, PTLD pathogenesis is not completely understood. PTLD appears to be at increasing risk after umbilical cord blood unrelated transplants (UCBT), mainly due to the graft immunoincompetence and slow engraft-ment, as well as to the use of antithymocyte globuline (ATG) in the preparative regimens.