Regional Therapeutic Strategies in Melanoma: Not Just Local Disease Control, but an Opportunity to Develop Novel Therapeutic Strategies with Potential Implications for Systemic Therapy

摘要

Since the initial description of isolated regional che-motherapeutic perfusion therapy in 1958 by Creech et al.,1 there have been surprisingly few modifications to this therapeutic intervention for advanced extremity melanoma over the last 50 years. In this issue of Annals of Surgical Oncology, Kroon et al. publish their manuscript entitled "Outcomes following isolated limb infusion for melanoma. A 14-year experience," which summarizes the Sydney Melanoma Unit's experience using melphalan and dacti-nomycin for regionally advanced melanoma administered through a minimally invasive regional chemotherapy procedure that they developed and initially described.