Differentially Expressed Circular RNAs in Degenerative Diseases Related to Low Back Pain: Potential of Circular RNAs as Biomarkers

摘要

Low back pain (LBP) is a main cause of disability around the world. Nevertheless, given the complex pathophysiology of LBP, the etiological diagnosis of LBP is a challenging process. Identifying appropriate biomarkers and/or therapeutic targets is still crucial for LBP research. There has been a growing interest in molecular biomarkers of LBP-related degenerative diseases. Recently, circular RNAs (circRNAs) have received great attention as microRNA (miRNA) sponges that inhibit normal miRNA activity. Due to their abundance and stability, circRNAs are considered as potential diagnostic biomarkers. Indeed, it has been reported that circulating or tissue-specific circRNAs can be used for diagnosing human diseases, including cancers, neurological diseases, and inflammatory diseases. Also of note, from 2015, research on circRNAs involved in LBP-related diseases is very active. Moreover, specific roles of some of the differentially expressed circRNAs have been demonstrated. Thus, the putative involvement of circRNAs in LBP-related diseases may suggest that some of the dysregulated circRNAs may have the potential to serve as therapeutic targets and/or diagnostic biomarkers for LBP. This review summarizes the current progress on differentially expressed circRNAs in diseases related to LBP.