Glucose Control in Severely Burned Patients Using Metformin An Interim Safety and Efficacy Analysis of a Phase II Randomized Controlled Trial

摘要

Objective: To determine whether metformin can achieve glucose control no worse than insulin (noninferiority) without the danger of hypoglycemia (superiority). In addition, to assess whether metformin has any additional effects on lipolysis and inflammation that will enhance burn recovery (superiority).