首页> 外文期刊>Annals of surgical oncology >Visceral obesity may affect oncologic outcome in patients with colorectal cancer.
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Visceral obesity may affect oncologic outcome in patients with colorectal cancer.

机译:内脏肥胖可能影响大肠癌患者的肿瘤学结局。

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PURPOSE: Obesity is closely related to the development of colorectal cancer as well as other metabolic complications. We investigated the prognostic significance of visceral obesity and body mass index (BMI) in 161 resectable colorectal cancer patients. METHODS: Ratios of visceral fat area (VFA) to subcutaneous fat area (SFA) were measured from the digital images of patients' computed tomography taken before the surgery, and patients were divided into those with high and those with low VFA/SFA ratio according to the degree of proportional visceral adiposity, and into an overweight and a normal-weight group according to their preoperative BMI. RESULTS: The overweight group showed a borderline decrease in cumulative disease-free survival compared to the normal-weight group (P = 0.064). Patients with high VFA/SFA ratio (more than 50 percentiles) had significantly lower cumulative disease-free survival rate compared to patients with low VFA/SFA ratio (P = 0.008). BMI and visceral adiposity showed no influence on overall survival of patients. CONCLUSION: Increased visceral adiposity was a significant predictor of disease-free survival in patients with resectable colorectal cancer. The prognostic significance of visceral adiposity should further be determined in a larger set of patients.
机译:目的:肥胖与大肠癌的发展以及其他代谢并发症密切相关。我们调查了内脏肥胖和体重指数(BMI)在161例可切除结直肠癌患者中的预后意义。方法:根据患者术前计算机断层扫描的数字图像,测量内脏脂肪面积(VFA)与皮下脂肪面积(SFA)的比值,将患者分为高,低VFA / SFA比值。内脏脂肪比例成比例,并根据术前BMI分为超重和正常体重组。结果:与正常体重组相比,超重组的无病累积生存率略有下降(P = 0.064)。 VFA / SFA比高的患者(大于50个百分位数)与VFA / SFA比低的患者相比,无病生存率显着降低(P = 0.008)。 BMI和内脏脂肪对患者的总生存没有影响。结论:内脏脂肪增多是可切除结直肠癌患者无病生存的重要预测指标。内脏肥胖的预后意义应在更多患者中进一步确定。

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