首页> 外文期刊>Bone marrow transplantation >Successful treatment of natural killer (NK) cell leukemia following a long-standing chronic active Epstein-Barr virus (CAEBV) infection with allogeneic bone marrow transplantation.
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Successful treatment of natural killer (NK) cell leukemia following a long-standing chronic active Epstein-Barr virus (CAEBV) infection with allogeneic bone marrow transplantation.

机译:同种异体骨髓移植长期以来长期慢性活动性爱泼斯坦-巴尔病毒(CAEBV)感染后,成功地治疗了自然杀伤(NK)细胞白血病。

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Summary:The optimal treatment for natural killer (NK) cell leukemia after chronic active Epstein-Barr virus (CAEBV) infection has not been determined. A 15-year-old boy presented with NK cell leukemia following CAEBV infection for 5 years. The peripheral blood and BM had an increased number of CD3(-)CD56(+) large granular lymphocytes and a monoclonal integration of the EBV genome was detected. Chemotherapy was not sufficiently effective to control the disease. Allogeneic BMT from an HLA-identical sister was performed using a conditioning regimen consisting of total body irradiation, cyclophosphamide and thiotepa. The patient is disease-free with a perfect performance status 24 months after BMT. This is the first report to show that allogeneic BMT is potentially able to cure NK cell leukemia after CAEBV infection.Bone Marrow Transplantation (2003) 31, 1169-1171. doi:10.1038/sj.bmt.1704078
机译:摘要:尚未确定慢性活动性爱泼斯坦-巴尔病毒(CAEBV)感染后自然杀伤(NK)细胞白血病的最佳治疗方法。一个15岁的男孩在CAEBV感染5年后出现NK细胞白血病。外周血和BM的CD3(-)CD56(+)大颗粒淋巴细胞数量增加,并且检测到EBV基因组的单克隆整合。化学疗法不足以控制疾病。来自HLA相同姐妹的同种异体BMT使用包括全身照射,环磷酰胺和thiotepa的调节方案进行。 BMT 24个月后,该患者无病,并且状态良好。这是第一份表明同种异体BMT可能能够治愈CAEBV感染后治愈NK细胞白血病的报道。骨髓移植(2003)31,1169-1171。 doi:10.1038 / sj.bmt.1704078

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