首页> 外文期刊>Annals of surgical oncology >Ratiometric Activatable Cell-Penetrating Peptides Label Pancreatic Cancer, Enabling Fluorescence-Guided Surgery, Which Reduces Metastases and Recurrence in Orthotopic Mouse Models
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Ratiometric Activatable Cell-Penetrating Peptides Label Pancreatic Cancer, Enabling Fluorescence-Guided Surgery, Which Reduces Metastases and Recurrence in Orthotopic Mouse Models

机译:比例激活的可穿透细胞的肽标记胰腺癌,可进行荧光引导手术,从而减少原位小鼠模型中的转移和复发。

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摘要

The aim of this study was to evaluate the efficacy of using matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9)-cleavable ratiometric activatable cell-penetrating peptides (RACPPs) conjugated to Cy5 and Cy7 fluorophores to accurately label pancreatic cancer for fluorescence-guided surgery (FGS) in an orthotopic mouse model.
机译:这项研究的目的是评估使用基质金属蛋白酶2(MMP-2)和基质金属蛋白酶9(MMP-9)可裂解的比例比例可活化细胞穿透肽(RACPP)与Cy5和Cy7荧光团偶联的功效标记的胰腺癌,用于原位小鼠模型中的荧光引导手术(FGS)。

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