Deoxygenative deuteration

摘要

Reducing carboxylic acids to aldehydes is not easy.The main difficulty encountered is over-reduction: anything strong enough to reduce a carboxylic acid is likely also able to reduce the aldehyde product.As such,the corresponding alcohol is easier to produce,and access to the aldehyde is typically achieved by selective reoxidation of the fully reduced product.Perhaps the most promising direct routes from carboxylic acids to aldehydes come from the recently developed photoredox methods,in which an acyl radical is formed through deoxygenation of the acid,followed by hydrogen atom transfer to form the aldehyde.