THE DYNAMICS OF SPINDLES AND EEG SLOW-WAVE ACTIVITY IN NREM SLEEP IN MICE

摘要

In 1960 Michel Jouvet described the occurrence of spindles and slow waves in sleeping cats (12). These hallmarks of sleep, together with the EOG and EMG, provided the basis for the definition of sleep stages in non-human mammals (12, 13). The occurrence of spindles during sleep has been since described in most mammalian species. A comparison of the sleep EEG in mouse strains suggested that their occurrence is determined by genetic factors (28, 29). Neurophysiological mechanisms of spindle oscillations are intimately related to the generation of slow waves (23).