GENES FOR PROSTAGLANDIN D SYNTHASE AND RECEPTOR AS WELL AS ADENOSINE A,A RECEPTOR ARE INVOLVED IN THE HOMEOSTATIC REGULATION OF NREM SLEEP

摘要

I would first like to join the other speakers in congratulating Professor Jouvet for the 50~(th) anniversary of his discovery of paradoxical sleep, and also to thank Dr. Luppi and other organizers for the kind invitation and warm hospitality. By way of introduction, I would like to briefly summarize our current view of how prostaglandin D2 exerts its somnogenic activity and then in the main part of my talk, I shall discuss more recent experimental results with gene manipulated mice.