Cancer after pre-eclampsia: follow up of the Jerusalem perinatal study cohort

摘要

Objective To compare the incidence of cancer among women with and without a history of pre-eclampsia.Design Cohort study.Setting Jerusalem perinatal study of women whodelivered in three large hospitals in West Jerusalemduring 1964-76.Participants 37 033 women.Main outcome measures Age adjusted and multivariable adjusted hazard ratios for cancer incidence for the entire cohort and for women whowere primiparous at study entry.Results Cancer developed in 91 women who had pre-eclampsia and 2204 who did not (hazard ratio1.27,95% confidence interval 1.03 to 1.57). The riskof site specific cancers was increased, particularly ofthe stomach, ovary epithelium, breast, and lung orlarynx. The incidence of cancer of the stomach, breast,ovary, kidney, and lung or larynx was increased inprimiparous women at study entry who had a historyof pre-eclampsia.Conclusions A history of pre-eclampsia is associated with increases in overall risk of cancer and incidenceat several sites. This may be explained byenvironmental and genetic factors common to thedevelopment of pre-eclampsia and cancer in thispopulation.