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Fluid boundaries between wake and sleep: experimental evidence from Stereo-EEG recordings

机译:唤醒和睡眠之间的流体边界:来自Stereo-EEG录音的实验证据

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Sleep and waking have been traditionally considered global behavioural states regulated by subcortical neuromodulatory circuits in a top-down fashion. Over the last years, we have been experiencing a paradigm shift towards a view that both wake and sleep are in essence local processes. Here we review recent clinical and basic research works supporting this view by taking advantage of stereotactic electroencephalography (Stereo-EEG, SEEG) recordings performed in epileptic patients. Specifically, we will discuss a growing body of evidence showing how electrophysiological features of sleep and wakefulness are coexisting across diffuse brain areas in pathological and physiological sleep as well as during state transitions (sleep onset and awakenings). Finally, we will discuss their implication for sleep medicine to extent that, reconsidering the classical definition of wakefulness and sleep as separate and mutually exclusive states may offer new insight for the understanding of parasomnias and other dissociated states.
机译:传统上,睡眠和苏醒被认为是由皮质下神经调节回路以自上而下的方式调节的整体行为状态。在过去的几年中,我们一直在经历着范式转变,即唤醒和睡眠本质上都是局部过程。在这里,我们通过利用在癫痫患者中进行的立体定向脑电图(Stereo-EEG,SEEG)记录来回顾支持这一观点的最新临床和基础研究工作。具体来说,我们将讨论越来越多的证据,这些证据表明在病理和生理性睡眠以及状态转换(睡眠发作和觉醒)期间,弥漫性大脑区域的睡眠和清醒的电生理特征如何共存。最后,我们将讨论它们对睡眠医学的影响,以至于重新考虑清醒和睡眠的经典定义,认为它们是独立且相互排斥的状态,可能为理解失眠症和其他分离状态提供新的见解。

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