Cryotherapy for the prevention of high-dose melphalan-induced oral mucositis.

摘要

High-dose melphalan (Ssl40mg/m2) alone or in combination with other chemotherapeutic agents or total body irradiation has been frequently used as conditioning for autologous or allogeneic hematopoietic stem cell transplantation (HSCT).1"3 Severe mucositis, however, remains as one of the major complications of high-dose melphalan. We read with great interest the recent article by Lilleby et al.,4 in which they reported the results of a prospective, randomized study of cryotherapy for the prevention of high-dose melphalan (200 mg/m2)-induced oral mucositits in patients undergoing autologous peripheral blood stem cell transplantation.