Urinary reactivation of polyoma BK virus but not adenovirus in paediatric and adolescent patients after haematopoietic stem cell transplantation.

摘要

Haemorrhagic cystitis (HC) after haematopoietic stem cell transplantation (HSCT) is closely related to viral reactivation. Risk factors for HC include busulfan-based conditioning, graft-versus-host disease (GVHD), and infections by viruses, notably polyoma BK virus (BKV)1-2 and adenovirus (AdV).In adult patients, we and others have consistently shown that BKV undergoes urinary reactivation.2-4-5 In paediatric patients, AdV reactivation has been reported to be a risk factor for HC.6 However, AdV-associated HC was reported mainly from Japan,7 but not observed in adult Chinese4 and Italian patients.