Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: How cooling is managed in the UK outside a clinical trial

摘要

The following mechanisms might explain the clinical benefit of PA: (i) ischaemic preconditioning seems to be the most likely explanation.4'11 PA could have prepared the heart and made it resistant to severe ischaemia associated with coronary artery occlusion in acute STEMI; (ii) PA could result in enhanced collateral blood flow, thereby limiting myocardial infarct size;12 (iii) PA may attenuate platelet-mediated thrombosis, thrombus composition, and thrombus burden in STEMI patients.13 Regardless of the exact underlying mechanisms, the important observations of Masci et a/.10 help explain the intriguing finding that PA results in less myocardial damage.