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Treatment of severe therapy-resistant acute graft-versus-host disease with human adipose tissue-derived mesenchymal stem cells.

机译:用人脂肪组织来源的间充质干细胞治疗重度耐药的急性移植物抗宿主病。

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摘要

Severe graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (ASCT), and a number of approaches are therefore being evaluated.1"5 Recently, Le Blanc et al6 reported a case of grade IV therapy-resistant acute GVHD of the gut and liver that showed rapid improvement after infusion of mesenchymal stem cells (MSCs). We here report a pilot study using human adipose tissue-derived MSC (AMSC) to treat severe acute GVHD after ASCT.
机译:严重的移植物抗宿主病(GVHD)是同种异体造血干细胞移植(ASCT)的致命并发症,因此正在评估多种方法。1“ 5最近,Le Blanc等[6]报告了一例IV级治疗骨髓间充质干细胞(MSCs)注入后对肠道和肝脏具有抵抗力的急性GVHD表现出快速的改善。本文报道了一项使用人脂肪组织源性MSC(AMSC)治疗ASCT后严重急性GVHD的初步研究。

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