Selective serotonin reuptake inhibitors in pregnancy and congenital malformations: population based cohort study

摘要

STUDY QUESTION Is there any association between selective serotonin reuptake inhibitors (SSRIs) taken during pregnancy and congenital major malformations?SUMMARY ANSWER There is an increased prevalence of septal heart defects among children whose mothers were prescribed an SSRl in early pregnancy, particularly sertraline, citalopram, or more than one type of SSRl.WHAT IS KNOWN AND WHATTHIS PAPER ADDS Theteratogenic effects of specific SSRIs are unconfirmed. The study found prescriptions for sertraline, citalopram, or more than one type of SSRl were associated with an increased prevalence of septal heart defects.