A Neurohormonal Role for Serotonin in the Control of Locust Oviducts

摘要

Serotonin increases the frequency and amplitude of spontaneous contractions and leads to an increase in the basal tonus of the locust oviducts.These effects were dose-dependent and were seen on both the non-innnervated and innervated portion of the oviducts.Vertebrate type serotonin agonists and antagonists were used and the profile shows that the receptors on the non-innervated and innervated portion of the oviducts are more similar to 5-HT_3 receptors than to either 5-HT_1 or 5-HT_2 receptors.No serotonin was found associated with the oviducts or the innervation to the oviducts using immunohistochemistry and HPLC coupled to electrochemical detection,suggesting a neurohormonal role for serotonin in the control of locust oviducts.