首页> 外文期刊>Archives of disease in childhood >Transcranial Doppler scanning and the assessment of stroke risk in children with haemoglobin sickle cell disease.
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Transcranial Doppler scanning and the assessment of stroke risk in children with haemoglobin sickle cell disease.

机译:经颅多普勒扫描和血红蛋白镰状细胞病患儿的中风风险评估。

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OBJECTIVE: To assess the role of transcranial Doppler (TCD) scanning in assessing the risk of stroke in children with haemoglobin SC (HbSC) disease. TCD scanning has an established role in primary stroke prevention in sickle cell anaemia but its value in HbSC is unknown. DESIGN: A retrospective audit of routinely performed TCD scans and routinely collected clinical data. SETTING: A paediatric sickle cell clinic in a teaching hospital in south London, UK. PATIENTS: 46 children with HbSC disease who have undergone routinely performed TCD scans and steady-state blood tests. MAIN OUTCOME MEASURES: The time-averaged mean of the maximum velocity (TAMMV) in the middle cerebral artery circulation correlated with clinical and laboratory data. RESULTS: The mean TAMMV was 94 cm/s, with a 98(th) centile of 128 cm/s. This is significantly less than the published ranges for HbSS, with a mean reading of 129 cm/s. One child had a stroke at the age of 5 years, when her TAMMV was measured at 146 cm/s. CONCLUSIONS: Further studies are needed to assess stroke risk in HbSC disease, but we suggest that TCD measurements are potentially useful in this condition, and that readings greater than 128 cm/s are abnormally high and warrant further investigation.
机译:目的:评估经颅多普勒(TCD)扫描在评估血红蛋白SC(HbSC)患儿中风风险中的作用。 TCD扫描在镰状细胞性贫血的一级卒中预防中已确立作用,但其在HbSC中的价值尚不清楚。设计:对常规进行的TCD扫描和常规收集的临床数据进行回顾性审核。地点:英国伦敦南部一家教学医院的小儿镰刀细胞诊所。患者:46名HbSC病患儿,他们定期进行了TCD扫描和稳态血液检查。主要观察指标:大脑中动脉循环中最大速度的平均时间平均值(TAMMV)与临床和实验室数据相关。结果:平均TAMMV为94 cm / s,第98个百分位为128 cm / s。这大大低于已发布的HbSS范围,平均读数为129 cm / s。一个孩子在5岁时中风,当时她的TAMMV为146 cm / s。结论:需要进一步的研究来评估HbSC疾病的中风风险,但是我们建议在这种情况下进行TCD测量可能是有用的,并且大于128 cm / s的读数异常高,需要进一步研究。

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