A New Biodegradable Adhesive for Protection of Intestinal Anastomoses. Preliminary Communication

摘要

Background and Aims: Anastomotic leaks continue to be a devastating complication for patients and surgeons worldwide. The few surgical adhesives available to date have not achieved the desired clinical results. The purpose of this experimental study was to determine if Pebisut ? applied to intestinal suture lines provides increased resistance and protection during the critical days of healing. Methods: Intestinal lesions were caused in rats and dogs and a new biodegradable adhesive (Pebisut ?) (patent granted in the European Union 07808494.4-1219, 01.12.2010, in Mexico P.C.T./MX/a/2009/001737, 16.02.2009, pending in the U.S.P.T.O. 60/762,136, 26.01.2006) was applied to compare the resistance of suture lines using bursting pressures and histologically. Results: Under acute and chronic conditions, Pebisut ? strengthened and made the suture lines more resistant, while histologically penetrating and sealing them. The adhesive disappears within 2-3 weeks and is well tolerated by the intestinal tissues. Conclusions: This biodegradable adhesive provides greater resistance, temporarily protects suture lines and may prevent anastomotic leaks.