Gender influences in vivo human responses to endotoxin.

摘要

To the Editor: Recently, Coyle et al. (1) reported their findings regarding gender differences during experimental human endotoxemia. In a subgroup of 16 males and 8 females, no significant differences in circulating white blood cells, cor-tisol, or cytokine levels were detected during the first 4 h after the administration of endotoxin (lipopolysaccharide [LPS]). The study appears well conducted, and one of the strong aspects includes measurements of blood levels of sex hormones.