Association of Two Well-defined Polymorphisms in Leptin and Leptin Receptor Genes with Hypertension and Circulating Leptin: A Meta-analysis

Li Ying-xue; Zhang Qi; Shang Xiao-ming; Li Yong-qiu; Liu Xiao-kun; Liu Chang-qing; Liu Xiao-ming; Zhang Qing-hua

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Association of Two Well-defined Polymorphisms in Leptin and Leptin Receptor Genes with Hypertension and Circulating Leptin: A Meta-analysis

机译：瘦素和瘦素受体基因的两个明确的多态性与高血压和循环瘦素的关联：荟萃分析

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Background and Aims. The genes encoding adipose-derived hormone leptin and its receptor (LEPR) are increasingly deemed as hypertension-susceptibility genes. In this meta-analysis, we summarized the association of the II/I polymorphism in leptin gene and Gln223Arg polymorphism in LEPR gene with hypertension and circulating leptin.

机译：背景和目标。编码脂肪来源的激素瘦素及其受体（LEPR）的基因越来越被认为是高血压易感基因。在这项荟萃分析中，我们总结了瘦素基因的II / I多态性和LEPR基因的Gln223Arg多态性与高血压和循环瘦素的相关性。

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《Archives of medical research》 |2015年第1期|共9页
作者
Li Ying-xue; Zhang Qi; Shang Xiao-ming; Li Yong-qiu; Liu Xiao-kun; Liu Chang-qing; Liu Xiao-ming; Zhang Qing-hua;
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正文语种 eng
中图分类医药、卫生;
关键词
Hypertension; Leptin; Leptin receptor; Polymorphism; Meta-analysis;

机译：高血压瘦素瘦素受体多态性元分析;

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1. Association of Two Well-defined Polymorphisms in Leptin and Leptin Receptor Genes with Hypertension and Circulating Leptin: A Meta-analysis [J] . Li Ying-xue, Zhang Qi, Shang Xiao-ming, Archives of medical research . 2015,第1期

机译：瘦素和瘦素受体基因的两个明确的多态性与高血压和循环瘦素的关联：荟萃分析
2. Association of polymorphisms of leptin, leptin receptor and apelin receptor genes with susceptibility to coronary artery disease and hypertension [J] . Nowzari Zohreh, Masoumi Mohammad, Nazari-Robati Mahdieh, Life sciences . 2018,第期

机译：瘦蛋白，瘦素受体和阿贝林受体基因多态性与冠状动脉疾病和高血压易感性的关系
3. Role of leptin receptor gene polymorphisms in susceptibility to the development of essential hypertension: A case-control association study in a Northern Han Chinese population [J] . LiuY., LouY.-Q., LiuK., Journal of human hypertension . 2014,第9期

机译：瘦素受体基因多态性在原发性高血压易感性中的作用：病例对照协会在北方汉族人群中的研究
4. Chronic Leptin Gene Delivery Desensitizes Leptin-Mediated STAT3 Transcription Factor Binding But Does Not FullyAccount For Leptin Resistance [C] . Philip J. Scarpace, Michael Matheny, Nihal Tumer Controlled Release Society annual meeting . 2004

机译：慢性瘦素基因传递使瘦素介导的STAT3转录因子结合不敏感，但不能完全说明瘦素抗性
5. Potent anorexic and lipopenic effects of central leptin gene therapy are blocked by diet-induced obesity: Evidence for impaired leptin receptor expression/signal transduction in obesity and reversal by caloric restriction. [D] . Wilsey, Jared Timothy. 2003

机译：饮食诱导的肥胖症会阻止中央瘦素基因疗法的有效厌食症和脂肪减少症：肥胖症中瘦素受体表达/信号转导受损的证据以及受热量限制的逆转。
6. Leptin receptor gene polymorphisms and risk of hypertension: a meta-analysis [O] . Yingdong Lian, Zhijun Tang, Yuxi Xie, 2015

机译：瘦素受体基因多态性与高血压风险：一项荟萃分析
7. Association between circulating leptin concentration and G-2548A gene polymorphism in patients with breast cancer: a meta-analysis [O] . Ji-Qing Hao, Qian-Kun Zhang, Yi-Xin Zhou, 2019

机译：循环瘦素浓度与乳腺癌患者G-2548A基因多态性的关系：META分析

Association of Two Well-defined Polymorphisms in Leptin and Leptin Receptor Genes with Hypertension and Circulating Leptin: A Meta-analysis

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