The effect of loratadine in exercise-induced asthma.

摘要

AIMS: To assess the effect of loratadine in exercise induced asthma. METHODS: Randomised, double blind, placebo controlled study of 10 mg oral loratadine, once daily for three days in 11 children. At the end of the treatment period FEV(1) was measured, and patients were exercised on a treadmill. FEV(1) measurements were repeated at intervals after exercise. RESULTS: Loratadine significantly reduced the decrease in FEV(1) after exercise at two, five, 10, 15, and 30 minutes, compared with placebo (p < 0.05). However, the mean decrease in FEV(1) at five minutes was more than 15% of baseline in the loratadine group. CONCLUSIONS: Loratadine reduces, but does not prevent, exercise induced asthma in children.