Use of proton pump inhibitors and risk of hip fracture in relation to dietary and lifestyle factors: a prospective cohort study

摘要

STUDY QUESTION Do proton pump inhibitors (PPIs) increase the risk of hip fracture in postmenopausal women even after accounting for other lifestyle and dietary risk factors?SUMMARY ANSWER Regular use of PPIs was associated with an increased risk of hip fracture in postmenopausal women, particularly among those with a history of smoking.WHAT IS KNOWN AND WHATTHIS PAPER ADDS Previous studies of the association between PPI use and hip fracture have had limited information on important lifestyle and dietary factors associated with fracture. This study shows an increased risk of hip fracture even after controlling for these other factors, and risk seems limited to women with history of smoking.