Pericardial effusion in pediatric SCT recipients with thrombotic microangiopathy

摘要

Pericardial effusion (PEF) is a known complication of hematopoie-tic SCT (HSCT) that can result in significant morbidity and even death by causing acute cardiac tamponade. The exact incidence and risk factors are not well described, but retrospective reviews report PEF occurring in 0.2-19% of HSCT patients. Age, gender, preparative conditioning regimen, GVHD and CMV or EBV viremias have been suggested as potential risk factors. The initial symptoms of PEF can be nonspecific, thus early detection and identification may improve patient outcomes.