Author response: Pearls Oy-sters: Pembrolizumab-induced myasthenia gravis

摘要

Robbins et al. provide critically important observations regarding the complexity of checkpoint inhibitor-associated autoimmunity-in particular, overlap of autoimmune diseases, specifically myasthenia gravis. In our patient, there were unequivocal signs of ptosis with fatigue, which are pathognomonic for myasthenia gravis. There needs to be much greater understanding of checkpoint inhibitor autoimmune pathogenesis before making the conclusion that the acetylcholine receptor autoantibodies are a simple marker of autoimmunity, rather than being evidence of myasthenia gravis.