APOE E4 is associated with younger age at ischemic stroke onset but not with stroke outcome

摘要

Stroke outcome is determined by a complex interplay, where age and stroke severity are predominant predictors. Studies on hemorrhagic stroke indicate that APOE genotype is a predictor of poststroke outcomes,1'2 but results from studies on ischemic stroke are more conflicting.1' There is 1 study suggesting an influence of APOE genotype on age at ischemic stroke onset, and sex-specific effects on outcome have been reported.5 Taken together, there is a need for larger studies on APOE and ischemic stroke outcomes with integrated information on age, severity, and sex.