Genetic polymorphism of cytochrome P450 2E1 and the risk of nasopharyngeal carcinoma

摘要

Cytochrome P450 2E1 (CYP2E1) is a detoxifying enzyme that belongs to the phase I metabolism of xenobiotics. This enzyme is encoded by a highly polymorphic gene whose common polymorphism corresponds to the substitution of cytosine (C) and thymine (T) at position 1019(152031920). This polymorphism has been identified in several cancers including nasopharyngeal cancer (NPC). The study involved 124 patients with nasopharyngeal carcinoma, compared with 166 healthy controls. The presence or absence of the polymorphism is determined by PCR-RFLP. The frequency comparison between the two groups is determined by the chi(2) test. The analysis of our results showed a significant difference between the two groups regarding the mutant genotype (C2/C2) (5% vs. 0.5%, P = 0.04) and has a risk factor for NPC in Tunisia (OR = 8.39; Cl 95% [0.99-388.1]). Also, the C2 allele was significantly associated with the group of patients than the control group (6% vs. 2%, P = 0.016) and increased three times the risk of NPC in Tunisia (OR = 2.99, CI 95%. [1.12-8.79]). Our results confirm the results reported in other populations and emphasize the importance of the involvement of this gene in. the development of detoxification of the NPC, which seems more and more strongly associated with environmental factors.