Notch1 ligand signaling pathway activated in cervical cancer: poor prognosis with high-level JAG1/Notch1

Yousif Nasser Ghaly; Sadiq Alaa Muhammad; Yousif Maitham G.; Al-Mudhafar Rihab H.; Al-Baghdadi Jinan J.; Hadi Najah

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Notch1 ligand signaling pathway activated in cervical cancer: poor prognosis with high-level JAG1/Notch1

机译：Notch1配体信号通路在宫颈癌中激活：高水平的JAG1 / Notch1预后不良

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摘要

Notch signalings are regulated multiple cellular processes during cancer progression. We aimed to investigate the significance and prognostic value of expression of Notch1 and JAG1 in cervical cancer to determine whether they could serve as prognostic predictors.

机译：Notch信号在癌症进展过程中受到多个细胞过程的调节。我们旨在调查Notch1和JAG1表达在宫颈癌中的意义和预后价值，以确定它们是否可以作为预后指标。

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《Archives of gynecology and obstetrics.》 |2015年第4期|共6页
作者
Yousif Nasser Ghaly; Sadiq Alaa Muhammad; Yousif Maitham G.; Al-Mudhafar Rihab H.; Al-Baghdadi Jinan J.; Hadi Najah;
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正文语种 eng
中图分类妇产科学;
关键词
Cervical cancer; Notch1; JAG1; Survival rate;

机译：宫颈癌;Notch1;JAG1;存活率;

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专利

1. Notch1 ligand signaling pathway activated in cervical cancer: poor prognosis with high-level JAG1/Notch1 [J] . Yousif Nasser Ghaly, Sadiq Alaa Muhammad, Yousif Maitham G., Archives of gynecology and obstetrics. . 2015,第4期

机译：Notch1配体信号通路在宫颈癌中激活：高水平的JAG1 / Notch1预后不良
2. Valproic acid suppresses cervical cancer tumor progression possibly via activating Notch1 signaling and enhances receptor-targeted cancer chemotherapeutic via activating somatostatin receptor type II [J] . TsaiC., LeslieJ.S., Franko-TobinL.G., Archives of gynecology and obstetrics. . 2013,第2期

机译：丙戊酸可能通过激活Notch1信号传导来抑制子宫颈癌的进展，并通过激活II型生长抑素受体来增强针对受体的癌症化学疗法
3. Overexpression of Pofut1 and activated Notch1 may be associated with poor prognosis in breast cancer [J] . Wan Guoxing, Tian Lin, Yu Yuandong, Biochemical and Biophysical Research Communications . 2017,第1期

机译：Pofut1和活化Notch1的过度表达可能与乳腺癌预后不良有关
4. Phage Display as a Tool for Development of Novel Therapeutics for Breast Cancer: Targeting Human Delta-Like Ligand1 Notch1 Ligand [C] . Joana Galvao, Margarida Silva, Maria Cabral, PEGS . 2014

机译：噬菌体展示作为乳腺癌新疗法的开发的工具：靶向人δ样的配体1 Notch1配体
5. Disruption of the furin cleavage site in mouse Notch1 results in cardiovascular malformations due to hypomorphic Notch1 signaling. [D] . Oltmann, Meredith Leigh. 2009

机译：小鼠Notch1中弗林蛋白酶切割位点的破坏由于Notch1亚型的信号转导而导致心血管畸形。
6. High Expression of Integrin α3 Predicts Poor Prognosis and Promotes Tumor Metastasis and Angiogenesis by Activating the c-Src/Extracellular Signal-Regulated Protein Kinase/Focal Adhesion Kinase Signaling Pathway in Cervical Cancer [O] . Qiqiao Du, Wei Wang, Tianyu Liu, 2020

机译：整合素α3的高表达通过激活c-Src /细胞外信号调节蛋白激酶/粘着斑激酶信号传导途径来预测宫颈癌的不良预后并促进肿瘤转移和血管生成。
7. High-level Coexpression of JAG1 and NOTCH1 Is Observed in Human Breast Cancer and Is Associated with Poor Overall Survival [O] . Michael Reedijk, Silvia Odorcic, Lynn Chang, 2005

机译：在人乳腺癌中观察到JAG1和NOTCH1的高级共表达，与整体生存差有关

Notch1 ligand signaling pathway activated in cervical cancer: poor prognosis with high-level JAG1/Notch1

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