Systemic lupus erythematosus complicated with thymoma and pure red cell aplasia (PCRA). CR of both complications following thymectomy and allogeneic haematopoietic SCT (HSCT), but persistence of antinuclear antibodies (ANA)

摘要

The association of systemic lupus erythematosus (SLE) with thymoma occurs with significant frequency. An autoimmune disorder of the blood, pure red cell aplasia (PRCA), may also be associated with thymoma and SLE. However, the occurrence of all three disorders, SLE, PRCA and thymoma, in the same patient is extremely rare. We are aware of one single case in which PRCA following thymectomy supervened in a patient with SLE. Here we report the case of a patient who suffered from all three disorders, was thymectomised with a short-lived remission of PRCA and finally attained full remission of the same conditions following allogeneic haematopoietic SCT (allo-HSCT). However antinuclear antibodies (ANA) of the homogeneous subtype are still present at a significant titre over 1 year after transplant.