1-(N-(2-(2-Methoxyphenylthio)benzyl)-N-methylamino-3- aryloxypropan-2-ols:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities

Xin Wang; Dong Zhi Liu; Ai Jun Li

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1-(N-(2-(2-Methoxyphenylthio)benzyl)-N-methylamino-3- aryloxypropan-2-ols:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities

机译：1-(N-(2-(2-Methoxyphenylthio)benzyl)-N-methylamino-3- aryloxypropan-2-ols:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities

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摘要

A series of 1-(N-(2-(2-methoxyphenylthio)benzyl)-N-methylamino-3-aryloxypropan-2-ols derivatives were designed and synthesized based on 5-HT_(1A)/SSRI drugs design strategies.The synthesized compounds were evaluated for their dual 5-HT_(1A)/ 5-HTT activities.

机译：一系列的1 - (N - (2 - (2-methoxyphenylthio)苄基)- N

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来源
《Chinese Chemical Letters》 |2008年第1期|40-42|共3页
作者
Xin Wang; Dong Zhi Liu; Ai Jun Li;
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作者单位

School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China;

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正文语种英语
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关键词
Solute Carrier Family 6, Member 4 Protein; Dual; SLC6A4 geneactivity;

机译：溶质载体家族,成员4蛋白质;双重SLC6A4 geneactivity;

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1. 1-(N-(2-(2-Methoxyphenylthio)benzyl)-N-methylamino-3-aryloxypropan-2-ols: Synthesis and evaluation for dual 5-HT1A/SSRI activities [J] . Xin Wang, Dong Zhi Liu, Ai Jun Li 中国化学快报（英文版） . 2008,第001期
2. N-(2-(2-Methoxyphenylthio)benzyl)-2-aryloxyethylamines:Synthesis and evaluation for dual 5-HT1A/SSRI activities [J] . Xue Dan Wu, Dong Zhi Liu, Ai Jun Li, 中国化学快报（英文版） . 2008,第003期
3. 1-2-(2-Methoxyphenylthio) benzyl-4-arylpiperazines derivatives: Synthesis and evaluation for dual 5-HT1A/SSRI activities [J] . Xin Wang, Dong Zhi Liu, Ai Jun Li 中国化学快报（英文版） . 2008,第001期
4. New 3-(4-arylpiperazin-1-yl)-1-(benzobthiophen-3-yl)-2-methylpropanol derivatives:Synthesis and evaluation for dual 5-HT1A/SSRI activities [J] . Ai Jun Li, Xiao Hua Zhang, Xue Qin Zhou, 中国化学快报（英文版） . 2008,第004期
5. Arylpiperazine derivatives of diphenylsulfide:Synthesis and evaluation for dual 5-HT1A/SSRI activities [J] . Xue Dan Wu, Dong Zhi Liu, Ai Jun Li, 中国化学快报（英文版） . 2008,第003期
6. N-(2-(2-Methoxyphenylthio)benzyl)-2-aryloxyethylamines: Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities [J] . Xue Dan Wu, Dong Zhi Liu, Ai Jun Li Chinese Chemical Letters . 2008,第3期

机译：N-(2-(2-Methoxyphenylthio)benzyl)-2-aryloxyethylamines: Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities
7. 1-2-(2-Methoxyphenylthio)benzyl-4-arylpiperazines derivatives:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities [J] . Xin Wang, Dong Zhi Liu, Ai Jun Li Chinese Chemical Letters . 2008,第1期

机译：1-2-(2-Methoxyphenylthio)benzyl-4-arylpiperazines derivatives:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities
8. Piperazine-Derived α1D/1A Antagonist 1- Benzyl-N- (3-(4- (2-Methoxyphenyl) Piperazine-1-yl) Propyl) -1H- Indole-2- Carboxamide Induces Apoptosis in Benign Prostatic Hyperplasia Independently of α1-Adrenoceptor Blocking [O] . Qing Xiao, Qi-Meng Liu, Ru-Chao Jiang, 2020

机译：哌嗪衍生的α1d/ 1a拮抗剂1-苄基-n-（3-（4-（2-（2-甲氧基苯基）哌嗪-1-基）丙基）-1h-吲哚-2-甲酰胺独立于α1-诱导良性前列腺增生中的细胞凋亡adrenoceptor阻止

1-(N-(2-(2-Methoxyphenylthio)benzyl)-N-methylamino-3- aryloxypropan-2-ols:Synthesis and evaluation for dual 5-HT_(1A)/SSRI activities

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