Nanoscale aggregates of porphyrins:red-shifted absorption,enhanced absorbance and phototherapeutic activity

摘要

Supramolecular aggregation of fluorophores will result in a variable absorption spectrum,which is beneficial for tuning the photophysical properties and improving their functionalities.Herein,ordered aggregates of liposoluble porphyrin molecules are obtained from 5,10,15,20-tetrakis(4-aminophenyl)porphyrin(TAPP).The influences of the molecular structures,solvents and polymer surfactants have been investigated,and then tetrahydrofuran and pluronic F-127 are screened out to be the optimal candidates for forming ordered aggregates of TAPP.The as-prepared aggregates of TAPP(TAPP-O NPs)exhibit a red-shifted absorption spectrum of 50 nm,enhanced absorbance in the near infrared region and improved photothermal activity.Particularly,the good phototherapeutic effects of TAPP-O NPs highlight the potential of aggregated organic materials for biomedical applications.