Chronic Kidney Disease after Pediatric Hematopoietic Cell Transplant

摘要

The cumulative incidence of chronic kidney disease (CKD) varies from 13%-60% in adult studies [1-3] to as high as 62% in children . CKD usually becomes apparent 6-12 months after hematopoietic cell transplant (HCT), although it has been described as early as 2 months and as late as 10 years posttrans-plant. There are 3 distinct clinical manifestations of renal disease that can occur in the HCT patient: thrombotic microangiopathy (TMA), typically hemolytic uremic syndrome (HUS), and idiopathic CKD and nephrotic syndrome.