首页> 外文期刊>Bone marrow transplantation >Prevalence and risk factors associated with development of ocular GVHD defined by NIH consensus criteria
【24h】

Prevalence and risk factors associated with development of ocular GVHD defined by NIH consensus criteria

机译:通过NIH共识标准定义的与眼GVHD发生相关的患病率和危险因素

获取原文
获取原文并翻译 | 示例
       

摘要

We studied 172 patients for development of ocular graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (allo-SCT) from 2002 to 2009. Ocular GVHD was diagnosed in 60 patients (38%), with 27 (16%) being diagnosed at days 100 and 33 (23%) beyond day 100 for a 2-year cumulative incidence of 35% (95% confidence interval (CI), 2843). The positive and negative predictive values of a Schirmer I test score (using 5 mm as a cutoff) in predicting ocular GVHD (day 100) were 41 and 82%, respectively. In patients with ocular GVHD beyond day 100, extraocular manifestations of GVHD preceded the development of ocular GVHD in most patients (27 of 33, 81%). Prior acute skin GVHD (odds ratio 2.57, 95% CI 1.175.64, P0.019) and male recipients of female donors (odds ratio 2.57, 95% CI 1.096.06, P0.03) were independent risk factors for ocular GVHD. We recommend comprehensive ocular evaluation rather than a screening Schirmer's test to establish the diagnosis of ocular GVHD. Early diagnosis and preventive strategies in high-risk populations need to be studied in clinical trials to prevent devastating impact on quality of life in patients with prolonged ocular GVHD.
机译:我们研究了2002年至2009年异基因干细胞移植(allo-SCT)后172例发生眼部移植物抗宿主病(GVHD)的患者。60例患者(38%)被诊断为眼部GVHD,其中27例(16%)被诊断为在第100天后第100天和第33天被诊断出(23%),两年累计发生率为35%(95%置信区间(CI),2843)。 Schirmer I测试评分(以5 mm为临界值)在预测眼部GVHD(第100天)时的阳性和阴性预测值分别为41%和82%。在超过第100天的眼部GVHD患者中,大多数患者的眼外GVHD表现要早于眼部GVHD的发展(33人中27人,占81%)。既往急性皮肤GVHD(几率2.57,95%CI 1.175.64,P <0.019)和男性供体的女性接受者(几率2.57,95%CI 1.096.06,P <0.03)是眼部GVHD的独立危险因素。我们建议进行全面的眼部评估,而不是筛查Schirmer检验以建立眼部GVHD的诊断。需要在临床试验中研究高危人群的早期诊断和预防策略,以防止对长期眼GVHD患者的生活质量造成毁灭性影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号