Photophysical and Biological Studies with Organometallic Ruthenium Complexes of Selenodiazole Ligands

摘要

Abstract Substituted selenodiazoles (piazselenols) were used as ligands to synthesize organometallic ruthenium(II) piano-stool complexes using the precursors ([η 6 -cymene)RuX 2 (where x?=?Cl, Br and I). Analytical data suggested that two (η 6 -cymene)Ru motifs were present per ligand in the solid state. However, 1 H and 77 Se NMR in DMSO solution confirmed the dissociation of the selenodiazole ligand from the ruthenium center. Interestingly, selenodiazole with naphthalene substitutes possess excellent photophysical properties. It showed strong red fluorescence (576?nm) when excited at visible region (488?nm) and was found suitable for use as an imaging agent in HCT 116 cells. Among all ligands examined, only the nitro substituted selenodiazole showed potent anticancer activity against the A2780 cell line.