Nitric oxide synthase inhibition restores orthostatic tolerance in young vasovagal syncope patients

摘要

Objective Syncope is sudden transient loss of consciousness and postural tone with spontaneous recovery the most common form is vasovagal syncope (VVS). We previously demonstrated impaired postsynaptic adrenergic responsiveness in young VVS patients was reversed by blocking nitric oxide synthase (NOS). We hypothesised that nitric oxide may account for reduced orthostatic tolerance in young recurrent VVS patients.