Correlation between paraproteinaemia and viral reactivation after allo-SCT

摘要

They detected a paraproteinaemia incidence of 32%, multiple in the majority of cases, with a predominance of an IgG isotype and with equal kappa/lambda restriction. In this report, the most important risk factor for the development of post-transplant paraproteinaemia was CMV reactivation, which was more frequent when alemtuzumab was included in conditioning regimen. The authors also described a poorer OS in patients with paraproteinaemia, with relapse being the commonest cause of death in this group of patients. None of the patients with paraproteinaemia subsequently developed myeloma or a lymphoproliferative disorder and only one patient developed cryoglobulinemia. In this study, EBV reactivation was not monitored. Babel ef al.2 first reported the association between the occurrence of paraproteinaemia and EBV reactivation after renal transplantation. Since then, paraproteinaemia has been largely reported in solid organ transplant recipients reactivating EBV.