The impact of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism on transplant-related variables after allogeneic hematopoietic cell transplantation in patients receiving MTX as GVHD prophylaxis

摘要

Genomic screening before allogeneic hematopoietic cell transplantation has emerged as an investigational tool used to predict events that elicit subtle effects following transplantation. Single-nucleotide polymorphisms are by far the most prevalent type of variants in the human genome, with an average occurrence every several 100 bases. Most single-nucleotide polymorphisms have no known effect on gene function, but a proportion of them may alter the expression and/or biological activity of encoded proteins, contributing to variation in disease susceptibility and treatment toxicity.