Synthesis of New 2-(1(2H)-Phthalazinon-2-yl)acetamide and 3-(1(2H)-Phthalazinon-2-yl)propanamide Derivatives as Antinociceptive and Anti-inflammatory Agents.

摘要

As a consequence of our ongoing studies on heterocyclic compounds for new antinociceptive and anti-inflammatory agents bearing lactam functional group, new 2-[1(2H)-phthalazinon-2-yl]acetamide and 3-[1(2H)-phthalazinon-2-yl]propanamide derivatives have been synthesized. Among the compounds synthesized, compound 4e was found the most active derivative in terms of antinociceptive and anti-inflammatory activities, without gastric lesions and bleeding at the given dose.