Chapter 5 Informing the assessments

摘要

The key principles and assessments that are needed when considering OIR or AWR guidance have been outlined in Chapter 2. How these assessments might be made and whether the existing methods of appraisal are sufficient, or whether additional information, evidence and analysis might be useful, were not addressed. In this chapter we outline additional information and evidence that might be useful and a range of methods of analysis that could be used to inform each of the assessments and decisions within the algorithm. We take existing methods of NICE appraisal as an accepted starting point and focus instead on exploring what additional information and analysis might feasibly be included in appraisal and how it might be interpreted to inform the judgements required using a series of case studies. We also consider whether this type of additional information and analysis might be routinely required within appraisal or only when OIR or AWR appears to be particularly relevant, for example more sophisticated additional analysis might be required only if it is established that further research might in principle be worthwhile.Full details of each of the case studies are reported in Appendices 7-10. A separate technical appendix (see Appendix 6) is also provided that describes in detail how to carry out the calculations that can inform each of the assessments described in this chapter.