Prophylaxis with mycophenolate mofetil and CsA can decrease the incidence of severe acute GVHD after antithymocyte globulin-based reduced-intensity preparative regimen and allo-SCT from HLA-matched unrelated donors.

摘要

Acute GVHD (aGVHD) remains a matter of concern after reduced intensity conditioning (RIC) allo-SCT, and its incidence might be expected to be higher when using allogeneic grafts from HLA-matched unrelated donors (MUD). Thus, novel approaches for GVHD prophylaxis are needed in an RIC transplant setting to further decrease procedure-related toxicities, especially GVHD. In this regard, the use of mycophenolate mofetil (MMF) for prophylaxis of aGVHD is rapidly increasing. This report investigated the use of MMF-CsA combination for GVHD prophylaxis in comparison with CsA alone, in patients receiving antithymocyte globulin (ATG)-based RIC allo-SCT from an HLA-MUD.