TEG Lysis Shutdown Represents Coagulopathy in Bleeding Trauma Patients: Analysis of the PROPPR Cohort

摘要

Letter to the Editor: The authors would like to congratulate Dr Cardenas et al. (1) for adding additional insight into the authors' ongoing understanding of fibrinolysis shutdown in trauma. Activation of fibrinolysis early after injury with subsequent shutdown and concurrent coagulopathy related to impaired thrombin generation has been known for over 50 years (2). This large gap in the literature in understanding fibrinolysis in trauma is likely related to the reliance of using biomarkers to quantify fibrinolysis [D-Dimer and plasmin antiplasmin (PAP) complexes] that have half-life of greater than 12 h (3).