Self-assembly of glutathione S-transferase into nanowires

摘要

This study presents the Ni-ion-directed self-assembly of a C2-symmetric homodimeric enzyme into nanowires. A genetically introduced His-tag arm stretches out of the central structure of a C2-symmetric homodimer of glutathione S-transferase, which is used as a linker to recruit a second building block through interprotein metal coordination, forming self-assembled one-dimensional nano-structures with excellent enzymatic activity.