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Outcome of hematopoietic stem cell transplantation in patients with atypical chronic myeloid leukemia.

机译:非典型慢性粒细胞白血病患者造血干细胞移植的结果。

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Atypical chronic myeloid leukemia (aCML) occurs rarely and is associated with a poor prognosis when treated with conventional chemotherapy. We evaluated the outcome of aCML after allogeneic hematopoietic stem cell transplantation (HSCT). Nine patients were transplanted from HLA-identical siblings (n = 4), HLA-compatible unrelated donors (n = 4) or twin brother (n = 1). Median follow-up was 55 months after transplant (range, 9.1-118.1 months). One patient who was transplanted in advanced disease with bone marrow from his twin brother relapsed 19 months post transplant. This patient was successfully retransplanted from the original donor. All patients remained in complete remission. Analysis of the leukocyte chimerism of peripheral white blood cells and bone marrow buffy coat cells by VNTR-polymerase chain reaction (PCR) and single-nucleotide polymorphism real-time PCR revealed complete chimerism in all patients who had received an allogeneic transplant. One patient suffering from cerebral toxoplasmosis died 9 months post transplant. All other patients were alive at the time of analysis. Our findings suggest that the outcome of allogeneic or syngeneic transplantation in patients with aCML may not be worse than the outcome of transplantation for BCR-ABL-positive CML.
机译:非典型慢性粒细胞白血病(aCML)很少发生,并且在用常规化学疗法治疗时预后不良。我们评估了异基因造血干细胞移植(HSCT)后aCML的结果。 9名患者从与HLA相同的兄弟姐妹(n = 4),与HLA兼容的无关亲戚(n = 4)或双胞胎(n = 1)移植。中位随访时间为移植后55个月(9.1-118.1个月)。一名从他的双胞胎兄弟那里接受了晚期疾病骨髓移植的患者在移植后19个月复发。该患者已成功从原供者那里移植。所有患者均保持完全缓解。通过VNTR-聚合酶链反应(PCR)和单核苷酸多态性实时PCR分析外周白细胞和骨髓白细胞层白细胞的白细胞嵌合体,发现所有接受同种异体移植的患者完全嵌合。一名患有脑弓形虫病的患者在移植后9个月死亡。在分析时,所有其他患者还活着。我们的发现表明,aCML患者的同种异体或同基因移植的结果可能不会比BCR-ABL阳性CML的移植结果差。

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