Anti-inflammatory and antibacterial activity study of some novel quinazolinones

摘要

Anti-inflammatory and antibacterial activities of some novel quinazolinones were determined. Evaluation of anti-inflammatory activity of test compounds was performed using carra-geenan induced paw edema in rats. Oral administrationoT test compounds' 25~mg/kg and 50 mg/ kg reduced the paw edema significantly (P < 0.05) in a dose dependent manner compared to car-rageenan induced rats. The test compounds were also screened for their antibacterial activity against the strains of Staphylococcus aureus and Escherichia coli at the concentrations of 200 μg/ ml and 1 mg/ml. The test compounds showed better activity as that of the standard lincomycin at the tested higher concentration against S. aureus. None of the compounds exhibit comparable activity to that of the standard ceftazidime against E. coli.